Nitric oxide (NO): physiology and metabolism (lecture)
نویسندگان
چکیده
منابع مشابه
Nitric oxide (NO) in renal physiology and pathophysiology.
Endogenous NO is synthesized by nitric oxide synthases (NOS) which use L-arginine as substrate. The various isoforms of NOS are widely distributed within the kidney. Brain NOS (bNOS) and endothelial NOS (eNOS) are constitutively expressed and are both distributed in glomeruli and vasculature. In addition bNOS is found in epithelial tissue including macula densa and the collecting duct. Two stru...
متن کاملNitric oxide and oxygen metabolism.
Introduction Inhibition of mitochondrial respiration has been associated with the cytotoxicity of NO right from the beginning of NO research [1,2]. Recent findings have confirmed the importance of mitochondrial inhibition, but put the previous research into a new context. Here we review our findings that: (a) NO reversibly inhibits O2 consumption by isolated cytochrome oxidase, mitochondria, ne...
متن کاملCorrelation between Nitric oxide (NO) & Asymmetric dimethylargininie (ADMA) Hemoglobin
73/ Spring summer 2010, Vol.4, No. 1 Medical Laboratory Journal Correlation between Nitric oxide (NO) & Asymmetric dimethylargininie (ADMA) Hemoglobin Concentration in sickle cell patients Abstract Background and objectives: The importance of Nitric oxide (NO) and Asymmetric dimethylargininie (ADMA) in pathophysiology of Sickle cell disease (SCD) is being increasingly clarified. Since very few ...
متن کاملNitric oxide metabolism in wounds.
Arginine can be metabolized in wounds to nitric oxide and citrulline by nitric oxide synthase or to urea and ornithine by arginase. We investigated the expression of these arginine metabolic pathways over a 3-week period. Groups of 8-10 male Balb/C mice underwent a dorsal skin incision and subcutaneous polyvinyl alcohol sponge implantation. The animals were sacrificed at various times, and spon...
متن کاملPhysiology of nitric oxide in skeletal muscle.
In the past five years, skeletal muscle has emerged as a paradigm of "nitric oxide" (NO) function and redox-related signaling in biology. All major nitric oxide synthase (NOS) isoforms, including a muscle-specific splice variant of neuronal-type (n) NOS, are expressed in skeletal muscles of all mammals. Expression and localization of NOS isoforms are dependent on age and developmental stage, in...
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ژورنال
عنوان ژورنال: Andrology and Genital Surgery
سال: 2020
ISSN: 2412-8902,2070-9781
DOI: 10.17650/2070-9781-2020-21-3-75-79